Anxiolytic Activity of Methanolic Extract of Albizia Procera Leaves in Albino Rats

Background and Objectives: Anxiety is an exaggerated feeling of uncertainty and fear. Anxiety refers to the experience of nervousness, panic restlessness and tension. Neurotransmitters like serotonin, dopamine, noradrenaline and GABA generates anxiety. Now a day’s serotonin modulators and benzodiazepines are available to alleviate anxiety. Generally in adults, anxiety disorders are the most common class of mental disorders with a 12- month prevalence rate of 24.9%. The most common disorder was Specific phobias and social anxiety disorder. As compared with adults aged between 18-64, the lifetime prevalence was generally less for panic disorder, GAD, and SAD, but specific phobia and agoraphobia without a history of panic attacks were most common in adolescents between the age of 13-17 years. The present paper discussed the anti-anxiety potential of Albizia procera leaves. Albizia procera leaves contain flavonoids, steroids, tannins, saponins and alkaloids. Materials and Methods: Flavonoids were the major constituent for the anxiolytic activity. The effect of methanolic extract of Albizia procera leaves (200 and 400 mg kg^-1, orally, daily, 21 days) on anxiolytic activity was assessed by using a Modified elevated plus-maze apparatus and Light-dark box apparatus. Anxiety activity in rats was induced by restraint stress. Results: The results show that Open arm entries were increased and closed arm entries were decreased in Modified Elevated Plus-Maze Apparatus (MEPMA). Lightbox entries were increased and dark box entries were decreased in the Light and Dark Box model (LDB). Conclusion: Thus we can conclude that methanolic extract of Albizia procera leaves exhibits significant anxiolytic activity at a low dose (200 mg kg^-1) and high dose (400 mg kg^-1). Thus Albizia procera leaves is a promising herbal option in the pharmaceutical world.